Anesthetics were first administered very primitively, with little know about them. The first type to be discovered was ethers and later nitrous oxides. These were first used as drugs at parties and believed to transform people because of their personality change. Once its true use was discovered, the anesthesia had to be administered through a rag or inhaled from a bag. At this time, he anesthetic was simply inhaled till the patient passed out; this sometimes led to death from an overdose. Charles Jackson then invented ether-drops, a medicine placed on the gum to soothe toothaches. The rag soaked idea continued, but was placed in a bottle to allow a more potent dosage. Eventually, this idea evolved into what are now ventilators with a facemask, similar to what it used today. Dosages also began to become regulated in order to prevent accidental deaths. In modern days, airway masks are placed in the receiver’s windpipe to keep breathing regulated. Liquid anesthetics are also now injected directly into the blood stream via intravenous injection. This is because some adults object to having to breathe in an anesthetic. Even today the field of anesthesia continues to grow and become advanced. The most pressing topic on anesthesiologist’s hands currently is, "Why does anesthesia have the effect it does?"